首页 > 重组蛋白 > Human TXNIP Recombinant Protein

TXNIP (基因名), Thioredoxin-interacting protein (蛋白名), txnip_human.

产品名称:

Human TXNIP/ Thioredoxin-interacting protein Recombinant Protein
硫氧还蛋白相互作用蛋白

货号:

R1162h

商标:

EIAab^®

监管等级:

RUO

别名:

Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1, VDUP1

序列号:

Q9H3M7

来源:

E.coli

种属:

Human

标签:

His

序列:

1-391aa

预估分子量:

43.01 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human TXNIP Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 1q21.1 by HGNC 1q21.1 by Entrez Gene 1q21.1 by Ensembl

TXNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

功能:

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Hs.533977

SMR:

Q9H3M7

STRING:

9606.ENSP00000358323

KEGG:

hsa:10628

MIM:

606599

Pfam:

PF02752

Uniprot:

Q9H3M7

相关产品

Mouse Txnip ELISA Kit

序列长度:

391

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

391:

LLDDMDGSQD | SPIFMYAPEF | KFMPPPTYTE | VDPCILNNNV | Q

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis"

Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee

From: Human Reproduction

[1].

"Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3."

(PMID: 8086474)

[2].

"The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation."

(PMID: 20068034)

[3].

"hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip."

(PMID: 18541147)

[4].

"Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus."

(PMID: 17381501)

[5].

"Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2)."

(PMID: 17603038)

[6].

"VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression."

(PMID: 12821938)

[7].

"Structure of the N-terminal domain of human thioredoxin-interacting protein."

(PMID: 23519408)

[8].

"TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1."

(PMID: 21460850)

[9].

"The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis."

(PMID: 20172870)

[10].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[1].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人硫氧还蛋白相互作用蛋白(TXNIP)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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