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TSHR (基因名), Thyrotropin receptor (蛋白名), tshr_human.
产品名称:

Human TSHR/ Thyrotropin receptor Recombinant Protein
促甲状腺激素受体

货号:

R9855h

商标:
EIAab®
监管等级:
别名:

Thyroid-stimulating hormone receptor, TSH-R, LGR3

序列号:
P16473
来源:
E.coli
种属:
Human
标签:
His
序列:
290-413aa
预估分子量:
13.64 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
  • Human TSHR Protein
  • Human TSHR Protein
  • Human TSHR Protein
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Human TSHR Protein
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human TSHR Protein
The PCR product of human TSHR gene was determined by 1% Agarose stained with EB.
Human TSHR Protein
Recombinant human TSHR protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 14q24-q31 by HGNC 14q24-q31 by Entrez Gene 14q24-q31 by Ensembl
TSHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production (PubMed:12045258). Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function (PubMed:15775968).


功能:
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism.


亚细胞位置:
Cell membrane Multi-pass membrane protein Basolateral cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease."

[2].
"Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan."

[3].
"Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function."

[4].
"Thyrotropin receptor and thyroid transcription factor-1 genes variant in Chinese children with congenital hypothyroidism."

[5].
"Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy."
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