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TPSB2 (基因名), Tryptase beta-2 (蛋白名), tryb2_human.
产品名称:

Human TPSB2/ Tryptase beta-2 Recombinant Protein
类胰蛋白酶β2

货号:

R0258h

商标:
EIAab®
监管等级:
别名:

Tryptase II, Tryptase-2, TPS2

序列号:
P20231
来源:
E.coli
种属:
Human
标签:
His
序列:
31-275aa
预估分子量:
26.95 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cell Biology
Human TPSB2 Protein
规格 & 价格: cart
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Human TPSB2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 16p13.3 by HGNC 16p13.3 by Entrez Gene 16p13.3 by Ensembl
TPSB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.


功能:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.


亚细胞位置:
Secreted Released from the secretory granules upon mast cell activation.


该产品尚未在任何出版物中被引用。

[1].
"Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."

[2].
"Active monomers of human beta-tryptase have expanded substrate specificities."

[3].
"Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog."

[6].
"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."

[7].
"The structure of the human betaII-tryptase tetramer: fo(u)r better or worse."

[8].
"Human beta-tryptase is a ring-like tetramer with active sites facing a central pore."

[9].
"Characterization of a tryptase mRNA expressed in the human basophil cell line KU812."

[10].
"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."
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