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Trpv1 (基因名), Transient receptor potential cation channel subfamily V member 1 (蛋白名), trpv1_mouse.
产品名称:

Mouse Trpv1/ Transient receptor potential cation channel subfamily V member 1 Recombinant Protein
瞬态电压感受器阳离子通道亚科V成员1

货号:

R12152m

商标:
EIAab®
监管等级:
别名:

Osm-9-like TRP channel 1, Vanilloid receptor 1, OTRPC1, TrpV1

序列号:
Q704Y3
来源:
E.coli
种属:
Mouse
标签:
His
序列:
688-839aa
预估分子量:
16.72 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Mouse Trpv1 Protein
规格 & 价格: cart
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Mouse Trpv1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Mouse Trpv1 Protein
Recombinant mouse Trpv1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
Homotetramer. May also form a heteromeric channel with TRPV3 (By similarity). Interacts with CALM, PRKCM and CSK (By similarity). Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with PIRT (PubMed:18455988). Interacts with TMEM100 (PubMed:25640077).


功能:
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:15194687, PubMed:15489017). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia (PubMed:10764638). Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell projection Dendritic spine membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Mostly, but not exclusively expressed in postsynaptic dendritic spines.


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