首页 > 重组蛋白 > Human TRAF4 Recombinant Protein

TRAF4 (基因名), TNF receptor-associated factor 4 (蛋白名), traf4_human.

产品名称:

Human TRAF4/ TNF receptor-associated factor 4 Recombinant Protein
TNF受体相关因子4

货号:

R15310h

商标:

EIAab^®

监管等级:

RUO

别名:

Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, RING finger protein 83, MLN 62, CART1, MLN62, RNF83

序列号:

Q9BUZ4

来源:

E.coli

种属:

Human

标签:

His

序列:

1-194aa

预估分子量:

21.34 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human TRAF4 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human TRAF4 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 17q11.2 by HGNC 17q11.2 by Entrez Gene 17q11.2 by Ensembl

TRAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6.

功能:

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.

亚细胞位置:

Cytoplasm Nucleus Cytoplasm Perinuclear region Cell junction Tight junction Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytoskeleton

数据库链接

UniGene:

Hs.8375

SMR:

Q9BUZ4

STRING:

9606.ENSP00000262395

KEGG:

hsa:9618

MIM:

602464

Pfam:

PF00097

Uniprot:

Q9BUZ4

相关产品

Mouse Traf4 ELISA Kit

Mouse Traf4 CLIA Kit

Mouse Traf4 Protein

Mouse Traf4 Polyclonal Antibody

Mouse Traf4 Monoclonal Antibody

序列长度:

470

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

450:

470:

VRDDAVFIRA | AVELPRKILS |

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma."

(PMID: 7592751)

[2].

"Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis."

(PMID: 18953416)

[3].

"TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN."

(PMID: 18087216)

[4].

"TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF."

(PMID: 16052631)

[5].

"MEKK4 is an effector of the embryonic TRAF4 for JNK activation."

(PMID: 16157600)

[6].

"Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase."

(PMID: 12023963)

[7].

"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."

(PMID: 10514511)

[8].

"Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."

(PMID: 7490069)

[9].

"Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."

(PMID: 19937093)

[10].

"Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment."

(PMID: 20056178)

[1].

人TNF受体相关因子4(TRAF4)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人TNF受体相关因子4(TRAF4)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人TNF受体相关因子4(TRAF4)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人TNF受体相关因子4(TRAF4)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人TNF受体相关因子4(TRAF4)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人TNF受体相关因子4(TRAF4)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人TNF受体相关因子4(TRAF4)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人TNF受体相关因子4(TRAF4)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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