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TLR8 (基因名), Toll-like receptor 8 (蛋白名), tlr8_human.
产品名称:

Human TLR8/ Toll-like receptor 8 Recombinant Protein
toll样受体8

货号:

R1991h

商标:
EIAab®
监管等级:
别名:

CD288, UNQ249/PRO286

序列号:
Q9NR97
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human TLR8 Protein
规格 & 价格: cart
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Human TLR8 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: Xp22.2 by HGNC Xp22.2 by Entrez Gene Xp22.2 by Ensembl
TLR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer. Interacts with BTK. Interacts with SMPDL3B.


功能:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.


亚细胞位置:
Membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Three novel mammalian toll-like receptors: gene structure, expression, and evolution."

[2].
"Toll-like receptor 8 polymorphism and coronary artery disease."

[3].
"A functional toll-like receptor 8 variant is associated with HIV disease restriction."

[4].
"Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis."

[5].
"Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population."

[6].
"Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands."

[7].
"Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes."

[8].
"A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition."

[9].
"Multiple common variants for celiac disease influencing immune gene expression."

[10].
"Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis."
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