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TLR7 (基因名), Toll-like receptor 7 (蛋白名), tlr7_human.
产品名称:

Human TLR7/ Toll-like receptor 7 Recombinant Protein
Toll样受体7

货号:

R1950h

商标:
EIAab®
监管等级:
别名:

UNQ248/PRO285

序列号:
Q9NYK1
来源:
E.coli
种属:
Human
标签:
His
序列:
453-642aa
预估分子量:
20.9 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human TLR7 Protein
规格 & 价格: cart
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Human TLR7 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human TLR7 Protein
Recombinant human TLR7 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: Xp22.2 by HGNC Xp22.2 by Entrez Gene Xp22.2 by Ensembl
TLR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Interacts with SMPDL3B.


功能:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.


亚细胞位置:
Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome Lysosome Cytoplasmic vesicle Phagosome Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.


该产品尚未在任何出版物中被引用。

[1].
"A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression."

[2].
"Toll-like receptor polymorphisms and age-related macular degeneration."

[3].
"Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy."

[4].
"Three novel mammalian toll-like receptors: gene structure, expression, and evolution."

[5].
"Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes."

[6].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[7].
"Dengue hemorrhagic fever is associated with polymorphisms in JAK1."

[8].
"Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls."

[9].
"Multiple common variants for celiac disease influencing immune gene expression."

[10].
"TLR activation pathways in HIV-1-exposed seronegative individuals."
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