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DNTTIP1 (基因名), Deoxynucleotidyltransferase terminal-interacting protein 1 (蛋白名), tdif1_human.
产品名称:

Human DNTTIP1/ Deoxynucleotidyltransferase terminal-interacting protein 1 Recombinant Protein

货号:

R14020h

商标:
EIAab®
监管等级:
别名:

Terminal deoxynucleotidyltransferase-interacting factor 1, TdIF1, C20orf167, TDIF1

序列号:
Q9H147
来源:
E.coli
种属:
Human
标签:
His
序列:
1-329aa
预估分子量:
36.19 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human DNTTIP1 Protein
规格 & 价格: cart
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Human DNTTIP1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human DNTTIP1 Protein
Recombinant human DNTTIP1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 20q13.12 by HGNC 20q13.12 by Entrez Gene 20q13.12 by Ensembl
DNTTIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer and homodimer (PubMed:11473582, PubMed:25653165). A minor proportion may form homotrimers (PubMed:11473582). Interacts with ZNF541 (PubMed:21573134). Interacts with the terminal deoxynucleotidyltransferase DNTT (PubMed:11473582, PubMed:16371131). Interacts with TRERF1 (PubMed:16371131, PubMed:21573134). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).


功能:
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65."

[2].
"Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting."

[3].
"TdIF1 recognizes a specific DNA sequence through its Helix-Turn-Helix and AT-hook motifs to regulate gene transcription."

[4].
"TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm."

[5].
"Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity."

[6].
"Direct binding of TReP-132 with TdT results in reduction of TdT activity."

[7].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"The DNA sequence and comparative analysis of human chromosome 20."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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