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WARS (基因名), Tryptophan--tRNA ligase, cytoplasmic (蛋白名), sywc_human.
产品名称:

Human WARS/ Tryptophan--tRNA ligase, cytoplasmic Recombinant Protein
色氨酰tRNA合成酶,细胞质

货号:

R1748h

商标:
EIAab®
监管等级:
别名:

Interferon-induced protein 53, Tryptophanyl-tRNA synthetase, IFP53, TrpRS, IFI53, WRS

序列号:
P23381
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human WARS Protein
规格 & 价格: cart
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Human WARS Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q32.2 by HGNC 14q32.2 by Entrez Gene 14q32.2 by Ensembl
WARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Isoform 1 and isoform 2 interact with an oxidized form of GAPDH. GAPDH stimulates the aminoacylation activity of isoform 2.


功能:
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase."

[2].
"Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis."

[3].
"Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase."

[4].
"Tryptophanyl-tRNA synthetase gene polymorphisms and risk of incident myocardial infarction."

[5].
"Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity."

[6].
"Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells."

[7].
"Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains."

[8].
"A human aminoacyl-tRNA synthetase as a regulator of angiogenesis."

[9].
"The human gene encoding tryptophanyl-tRNA synthetase: interferon-response elements and exon-intron organization."

[10].
"Gamma interferon potently induces tryptophanyl-tRNA synthetase expression in human keratinocytes."
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