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SORBS1 (基因名), Sorbin and SH3 domain-containing protein 1 (蛋白名), srbs1_human.
产品名称:

Human SORBS1/ Sorbin and SH3 domain-containing protein 1 Recombinant Protein
含有Sorbin和SH3结构域的蛋白1

货号:

R3361h

商标:
EIAab®
监管等级:
别名:

Ponsin, SH3 domain protein 5, SH3P12, c-Cbl-associated protein, CAP, KIAA0894, KIAA1296, SH3D5

序列号:
Q9BX66
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SORBS1 Protein
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Human SORBS1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q24.1 by HGNC 10q24.1 by Entrez Gene 10q24.1 by Ensembl
SORBS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN.


功能:
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.


亚细胞位置:
Cell junction Adherens junction Cell membrane Cytoplasm Cytoskeleton Cell junction Focal adhesion Nucleus Nucleus matrix Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.


该产品尚未在任何出版物中被引用。

[1].
"Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes."

[2].
"Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study."

[3].
"Paxillin and ponsin interact in nascent costameres of muscle cells."

[4].
"Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism."

[5].
"Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions."
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