首页 > 重组蛋白 > Human SREBF2 Recombinant Protein

SREBF2 (基因名), Sterol regulatory element-binding protein 2 (蛋白名), srbp2_human.

产品名称:

Human SREBF2/ Sterol regulatory element-binding protein 2 Recombinant Protein
固醇调节元件结合蛋白2

货号:

R12196h

商标:

EIAab^®

监管等级:

RUO

别名:

Class D basic helix-loop-helix protein 2, Sterol regulatory element-binding transcription factor 2, bHLHd2, SREBP-2, BHLHD2, SREBP2

序列号:

Q12772

来源:

E.coli

种属:

Human

标签:

His

序列:

331-470aa

预估分子量:

15.4 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cardiovascular

规格 & 价格:

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产品说明书

说明书:

MSDS:

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数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human SREBF2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 22q13.2 by HGNC 22q13.2 by Entrez Gene 22q13.2 by Ensembl

SREBF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminal domain) with RNF139.

功能:

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

亚细胞位置:

Processed sterol regulatory element-binding protein 2 Nucleus

数据库链接

UniGene:

Hs.443258

SMR:

Q12772

STRING:

9606.ENSP00000354476

KEGG:

hsa:6721

MIM:

600481

Pfam:

PF00010

Uniprot:

Q12772

相关产品

Mouse Srebf2 ELISA Kit

Rat Srebf2 ELISA Kit

Mouse Srebf2 CLIA Kit

Rat Srebf2 CLIA Kit

Mouse Srebf2 Protein

序列长度:

1141

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1141:

QRAVLLAEAA | RTLEKVGDRR | SCNDCQQMIV | KLGGGTAIAA | S

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element."

(PMID: 7903453)

[2].

"Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population."

(PMID: 19740467)

[3].

"The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage."

(PMID: 19706601)

[4].

"Polymorphism of the sterol regulatory element-binding protein-2 gene and its association with serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations."

(PMID: 19263511)

[5].

"Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population."

(PMID: 18954446)

[6].

"Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death."

(PMID: 19116028)

[7].

"The effect of sterol regulatory element-binding protein 2 polymorphism on the serum lipid in northern Chinese subjects."

(PMID: 15547298)

[8].

"Analysis of the SREBF2 gene as a genetic risk factor for vascular dementia."

(PMID: 16082694)

[9].

"Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes."

(PMID: 16158080)

[10].

"[Relations between polymorphism of sterol regulatory element binding protein-2 gene and hyperlipidemia in the Han ethics of China]."

(PMID: 15211801)

[1].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人固醇调节元件结合蛋白2(SREBF2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人固醇调节元件结合蛋白2(SREBF2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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