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SPTAN1 (基因名), Spectrin alpha chain, brain (蛋白名), spta2_human.
产品名称:

Human SPTAN1/ Spectrin alpha chain, brain Recombinant Protein
大脑血影蛋白α链

货号:

R0292h

商标:
EIAab®
监管等级:
别名:

Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha chain, SPTA2

序列号:
Q13813
来源:
E.coli
种属:
Human
标签:
His
序列:
149-253aa
预估分子量:
11.55 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SPTAN1 Protein
规格 & 价格: cart
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Human SPTAN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 9q34.11 by HGNC 9q34.11 by Entrez Gene 9q34.11 by Ensembl
SPTAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM and EMD. Interacts (via C-terminal spectrin repeats) with TRPC4. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1.


功能:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.


亚细胞位置:
Cytoplasm cytoskeleton Cytoplasm cell cortex Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.


该产品尚未在任何出版物中被引用。

[1].
"Brain and muscle express a unique alternative transcript of alphaII spectrin."

[2].
"Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility."

[3].
"Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[6].
"Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay."

[7].
"AlphaII-spectrin is critical for cell adhesion and cell cycle."

[8].
"The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG."

[9].
"Knockdown of alphaII spectrin in normal human cells by siRNA leads to chromosomal instability and decreased DNA interstrand cross-link repair."

[10].
"The immunogenic SigA enterotoxin of Shigella flexneri 2a binds to HEp-2 cells and induces fodrin redistribution in intoxicated epithelial cells."
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