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SERPINB3 (基因名), Serpin B3 (蛋白名), spb3_human.
产品名称:

Human SERPINB3/ Serpin B3 Recombinant Protein
丝氨酸蛋白酶B3

货号:

R1372h

商标:
EIAab®
监管等级:
别名:

Protein T4-A, Squamous cell carcinoma antigen 1, SCCA-1, SCCA, SCCA1

序列号:
P29508
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SERPINB3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 18q21.33 by HGNC 18q21.33 by Entrez Gene 18q21.33 by Ensembl
SERPINB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MAPK8/JNK1.


功能:
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).


亚细胞位置:
Cytoplasm Seems to also be secreted in plasma by cancerous cells but at a low level.



[1].
"A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."

[2].
"Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease."

[3].
"Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma."

[4].
"Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells."

[5].
"Update of the human and mouse SERPIN gene superfamily."

[6].
"Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD."

[7].
"Risk of meningioma and common variation in genes related to innate immunity."

[8].
"Polymorphisms in innate immunity genes and risk of childhood leukemia."

[9].
"Up-regulation of serpin SCCA1 is associated with epidermal barrier disruption."

[10].
"Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase."
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