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SOX2 (基因名), Transcription factor SOX-2 (蛋白名), sox2_human.
产品名称:

Human SOX2/ Transcription factor SOX-2 Recombinant Protein
转录因子SOX-2

货号:

R0423h

商标:
EIAab®
监管等级:
序列号:
P48431
来源:
E.coli
种属:
Human
标签:
His
序列:
CMETELKPPGPQQTSGGGGGNST
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SOX2 Protein
规格 & 价格: cart
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Human SOX2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 3q26.33 by HGNC 3q26.33 by Entrez Gene 3q26.33 by Ensembl
SOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.


功能:
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study."

[2].
"The cDNA sequence and chromosomal location of the human SOX2 gene."

[3].
"Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma."

[4].
"Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus."

[5].
"Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases."

[6].
"SOX2 modulates alternative splicing in transitional cell carcinoma."

[7].
"Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology."

[8].
"Novel SOX2 partner-factor domain mutation in a four-generation family."

[9].
"Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma."

[10].
"Helicobacter pylori induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4-mediated HMG box protein Sox2 expression."
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