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AANAT (基因名), Serotonin N-acetyltransferase (蛋白名), snat_human.
产品名称:

Human AANAT/ Serotonin N-acetyltransferase Recombinant Protein
5-羟色胺-N-乙酰基转移

货号:

R1937h

商标:
EIAab®
监管等级:
别名:

Aralkylamine N-acetyltransferase, AA-NAT, Serotonin acetylase, SNAT

序列号:
Q16613
来源:
E.coli
种属:
Human
标签:
His
序列:
1-70aa
预估分子量:
7.7 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human AANAT Protein
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Human AANAT Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human AANAT Protein
Recombinant human AANAT protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 17q25.1 by HGNC 17q25.1 by Entrez Gene 17q25.1 by Ensembl
AANAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation.


功能:
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome."

[2].
"The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression."

[3].
"Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis."

[4].
"Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese."

[5].
"A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production."

[6].
"Genetic variability of arylalkylamine-N-acetyl-transferase (AA-NAT) gene and human sleep/wake pattern."

[7].
"cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation."

[8].
"Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population."

[9].
"Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis."

[10].
"Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility."
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