EIAab
首页  >  重组蛋白  >  Human KITLG Recombinant Protein
KITLG (基因名), Kit ligand (蛋白名), scf_human.
产品名称:

Human KITLG/ Kit ligand Recombinant Protein
Kit配合基

货号:

R0120h

商标:
EIAab®
监管等级:
别名:

Mast cell growth factor, Stem cell factor, c-Kit ligand, MGF, SCF, MGF, SCF

序列号:
P21583
来源:
E.coli
种属:
Human
标签:
His
序列:
26-190aa
预估分子量:
18.15 kDa (monomer)
纯度:
Greater than 98% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human KITLG Protein
  • Human KITLG Protein
  • Human KITLG Protein
规格 & 价格: cart
×
Human KITLG Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human KITLG Protein
The PCR product of human KITLG gene was determined by 1% Agarose stained with EB.
Human KITLG Protein
Recombinant human KITLG protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 12q21.32 by HGNC 12q21.32 by Entrez Gene 12q21.32 by Ensembl
KITLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.


功能:
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.


亚细胞位置:
Soluble KIT ligand Secreted


该产品尚未在任何出版物中被引用。

[1].
"Allelic Mutations of KITLG, Encoding KIT Ligand, Cause Asymmetric and Unilateral Hearing Loss and Waardenburg Syndrome Type 2."

[2].
"Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."

[3].
"Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor."

[4].
"Genetic determinants of hair, eye and skin pigmentation in Europeans."

[5].
"Structure of the active core of human stem cell factor and analysis of binding to its receptor kit."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com