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PDXP (基因名), Pyridoxal phosphate phosphatase (蛋白名), plpp_human.
产品名称:

Human PDXP/ Pyridoxal phosphate phosphatase Recombinant Protein
吡哆醛磷酸盐磷酸

货号:

R1712h

商标:
EIAab®
监管等级:
别名:

Chronophin, PLP phosphatase, CIN, PLP, PLPP

序列号:
Q96GD0
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human PDXP Protein
规格 & 价格: cart
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Human PDXP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 22q13.1 by HGNC 22q13.1 by Entrez Gene 22q13.1 by Ensembl
PDXP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer.


功能:
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.


亚细胞位置:
Cytoplasm Cytosol Cytoplasm Cytoskeleton Cell projection Ruffle membrane Peripheral membrane protein Cytoplasmic side Cell projection Lamellipodium membrane Peripheral membrane protein Cytoplasmic side Cell membrane Peripheral membrane protein Cytoplasmic side Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.


该产品尚未在任何出版物中被引用。

[1].
"Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics."

[2].
"Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution."

[3].
"Identification of an essential cysteine residue in pyridoxal phosphatase from human erythrocytes."

[4].
"A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation."

[5].
"Human brain pyridoxal-5'-phosphate phosphatase (PLPP):protein transduction of PEP-1-PLPP into PC12 cells."

[6].
"Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation."

[7].
"Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2."

[8].
"Human brain pyridoxal-5'-phosphate phosphatase: production and characterization of monoclonal antibodies."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"The DNA sequence of human chromosome 22."
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