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PGF (基因名), Placenta growth factor (蛋白名), plgf_human.
产品名称:

Human PGF/ Placenta growth factor Recombinant Protein
胎盘生长因子

货号:

R0114h

商标:
EIAab®
监管等级:
别名:

PlGF, PGFL, PLGF

序列号:
P49763
来源:
E.coli
种属:
Human
标签:
His
序列:
19-221aa
预估分子量:
22.33 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human PGF Protein
规格 & 价格: cart
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Human PGF Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q24.3 by HGNC 14q24.3 by Entrez Gene 14q24.3 by Ensembl
PGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is found both as homodimer and as monomer.


功能:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.


亚细胞位置:
Secreted The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.


该产品尚未在任何出版物中被引用。

[1].
"Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells."

[2].
"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14."

[3].
"A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta."

[4].
"Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor."

[5].
"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF."

[6].
"Placenta growth factor in sickle cell disease: association with hemolysis and inflammation."

[7].
"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes."

[8].
"A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)."

[9].
"Mutation analysis of the growth factor genes PlGF, Flt1, IGF-I, and IGF-IR in intrauterine growth restriction with abnormal placental blood flow."

[10].
"Relationship between serum vasoactive factors and plaque morphology in patients with non-ST-segment elevated acute coronary syndrome."
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