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OAZ3 (基因名), Ornithine decarboxylase antizyme 3 (蛋白名), oaz3_human.
产品名称:

Human OAZ3/ Ornithine decarboxylase antizyme 3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

AZ3

序列号:
Q9UMX2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human OAZ3 Protein
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Human OAZ3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 1q21.3 by HGNC 1q21.3 by Entrez Gene 1q21.3 by Ensembl
OAZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240). Interacts with GGN.


功能:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.


亚细胞位置:
Nucleus Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3."

[2].
"Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3."

[3].
"Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."

[4].
"ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1."

[5].
"Architecture of the human interactome defines protein communities and disease networks."

[6].
"A proteome-scale map of the human interactome network."

[7].
"Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability."

[8].
"Proteomic characterization of the human sperm nucleus."

[9].
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."

[10].
"Antizyme 3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation."
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