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OAZ1 (基因名), Ornithine decarboxylase antizyme 1 (蛋白名), oaz1_human.
产品名称:

Human OAZ1/ Ornithine decarboxylase antizyme 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

AZ1, OAZ

序列号:
P54368
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cell Biology
Human OAZ1 Protein
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Human OAZ1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
OAZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with ODC1 and thereby sterically blocks ODC homodimerization (PubMed:26305948, PubMed:26443277). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (PubMed:12097147). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240).


功能:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147).


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme."

[2].
"Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events."

[3].
"Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization."

[4].
"Molcecular cloning of human antizyme cDNA."

[5].
"Structural basis of antizyme-mediated regulation of polyamine homeostasis."

[6].
"Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."

[7].
"Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells."

[8].
"Regulation of all members of the antizyme family by antizyme inhibitor."

[9].
"[Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population]."

[10].
"The DNA sequence and biology of human chromosome 19."
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