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Nckap1 (基因名), Nck-associated protein 1 (蛋白名), nckp1_mouse.
产品名称:

Mouse Nckap1/ Nck-associated protein 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Brain protein H19, MH19, Membrane-associated protein HEM-2, p125Nap1, NAP 1, Hem2, Kiaa0587, Nap1

序列号:
P28660
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Mouse Nckap1 Protein
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Mouse Nckap1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Associates preferentially with the first SH3 domain of NCK (By similarity). Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with NYAP1, NYAP2 and MYO16.


功能:
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).


亚细胞位置:
Cell membrane Single-pass membrane protein Cytoplasmic side Cell projection Lamellipodium membrane Single-pass membrane protein Cytoplasmic side Cytoplasm At the interface between the lamellipodial actin meshwork and the membrane.


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