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NLRP4 (基因名), NACHT, LRR and PYD domains-containing protein 4 (蛋白名), nalp4_human.
产品名称:

Human NLRP4/ NACHT, LRR and PYD domains-containing protein 4 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Cancer/testis antigen 58, PAAD and NACHT-containing protein 2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, Ribonuclease inhibitor 2, CT58, PAN2, PYPAF4, NALP4, PAN2, PYPAF4, RNH2

序列号:
Q96MN2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human NLRP4 Protein
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Human NLRP4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 19q13.43 by HGNC 19q13.43 by Entrez Gene 19q13.43 by Ensembl
NLRP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CHUK/IKKA, inhibiting its kinase activity.


功能:
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"NALPs: a novel protein family involved in inflammation."

[2].
"Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1."

[3].
"Structural and functional analysis of the NLRP4 pyrin domain."

[4].
"NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4."

[5].
"The genetics of NOD-like receptors in Crohn's disease."

[6].
"Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia."

[7].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[8].
"Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing."
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