首页 > 重组蛋白 > Human MYD88 Recombinant Protein

MYD88 (基因名), Myeloid differentiation primary response protein MyD88 (蛋白名), myd88_human.

产品名称:

Human MYD88/ Myeloid differentiation primary response protein MyD88 Recombinant Protein
骨髓分化一级反应蛋白MyD88

货号:

R1707h

商标:

EIAab^®

监管等级:

RUO

序列号:

Q99836

来源:

E.coli

种属:

Human

标签:

His

序列:

159-296aa

预估分子量:

15.18 kDa (monomer)

纯度:

Greater than 98% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

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Human MYD88 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 3p22.2 by HGNC 3p22.2 by Entrez Gene 3p22.2 by Ensembl

MYD88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1.

功能:

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Hs.82116

SMR:

Q99836

STRING:

9606.ENSP00000401399

KEGG:

hsa:4615

MIM:

602170

Pfam:

PF00531

Uniprot:

Q99836

相关产品

Mouse Myd88 ELISA Kit

Rat Myd88 ELISA Kit

Bovine MYD88 ELISA Kit

Chicken MYD88 ELISA Kit

Pig MYD88 ELISA Kit

序列长度:

296

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

296:

RLIPIKYKAM | KKEFPSILRF | ITVCDYTNPC | TKSWFWTRLA | KALSLP

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins."

(PMID: 19265123)

[2].

"Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling."

(PMID: 19506249)

[3].

"Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."

(PMID: 18292575)

[4].

"Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6."

(PMID: 15361868)

[5].

"The cloning and characterization of human MyD88: a member of an IL-1 receptor related family."

(PMID: 9013863)

[6].

"Molecular characterization and modular analysis of human MyD88."

(PMID: 8957090)

[7].

"Functional assessment of the mutational effects of human IRAK4 and MyD88 genes."

(PMID: 24316379)

[8].

"IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."

(PMID: 23453969)

[9].

"MYD88 L265P somatic mutation in Waldenstr?m's macroglobulinemia."

(PMID: 22931316)

[10].

"Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly."

(PMID: 20966070)

[1].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人骨髓分化一级反应蛋白MyD88(MYD88)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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Human MYD88/ Myeloid differentiation primary response protein MyD88 Recombinant Protein骨髓分化一级反应蛋白MyD88

R1707h

Human MYD88/ Myeloid differentiation primary response protein MyD88 Recombinant Protein
骨髓分化一级反应蛋白MyD88