首页 > 重组蛋白 > Human MCTS1 Recombinant Protein

MCTS1 (基因名), Malignant T-cell-amplified sequence 1 (蛋白名), mcts1_human.

产品名称:

Human MCTS1/ Malignant T-cell-amplified sequence 1 Recombinant Protein
恶性T细胞扩增序列1

货号:

R15021h

商标:

EIAab^®

监管等级:

RUO

别名:

Multiple copies T-cell malignancies, MCT-1, MCT1

序列号:

Q9ULC4

来源:

E.coli

种属:

Human

标签:

His

序列:

Recombinant protein

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human MCTS1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: Xq24 by HGNC Xq24 by Entrez Gene Xq24 by Ensembl

MCTS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts (via PUA domain) with DENR.

功能:

Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

亚细胞位置:

Cytoplasm Nuclear relocalization after DNA damage.

数据库链接

UniGene:

Hs.102696

SMR:

Q9ULC4

STRING:

9606.ENSP00000360365

KEGG:

hsa:28985

MIM:

300587

Pfam:

PF01472

Uniprot:

Q9ULC4

相关产品

Mouse Mcts1 ELISA Kit

Rat Mcts1 ELISA Kit

Bovine MCTS1 ELISA Kit

Chicken MCTS1 ELISA Kit

Mouse Mcts1 CLIA Kit

序列长度:

181

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

181:

SAEDIEKVNK | GIGIENIHYL | NDGLWHMKTY | K

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles."

(PMID: 16982740)

[2].

"A novel candidate oncogene, MCT-1, is involved in cell cycle progression."

(PMID: 9766643)

[3].

"DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth."

(PMID: 25043021)

[4].

"Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."

(PMID: 20713520)

[5].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[6].

"Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies."

(PMID: 12637315)

[7].

"Expression and stabilization of the MCT-1 protein by DNA damaging agents."

(PMID: 11709712)

[8].

"Architecture of the human interactome defines protein communities and disease networks."

(PMID: 28514442)

[9].

"Structural and Functional Insights into Human Re-initiation Complexes."

(PMID: 28732596)

[10].

"Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1."

(PMID: 28723557)

[1].

人恶性T细胞扩增序列1(MCTS1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人恶性T细胞扩增序列1(MCTS1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人恶性T细胞扩增序列1(MCTS1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人恶性T细胞扩增序列1(MCTS1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人恶性T细胞扩增序列1(MCTS1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人恶性T细胞扩增序列1(MCTS1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人恶性T细胞扩增序列1(MCTS1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人恶性T细胞扩增序列1(MCTS1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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