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Macf1 (基因名), Microtubule-actin cross-linking factor 1 (蛋白名), macf1_rat.
产品名称:

Rat Macf1/ Microtubule-actin cross-linking factor 1 Recombinant Protein
微管肌动蛋白交联因子1,亚型1/2/3/5

货号:

R15471r

商标:
EIAab®
监管等级:
别名:

Actin cross-linking family 7, Acf7, Aclp7, Macf

序列号:
D3ZHV2
来源:
E.coli
种属:
Rat
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Rat Macf1 Protein
规格 & 价格: cart
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Rat Macf1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Interacts with MAPRE1, CLASP1, CLASP2 and GOLGA4 (By similarity). Interacts with AXIN1 and LRP6. Found in a complex composed of MACF1, APC; AXIN1, CTNNB1 and GSK3B.


功能:
F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.


亚细胞位置:
Cytoplasm Cytoskeleton Cytoplasm Membrane Cell membrane Cell projection Ruffle membrane Localizes to the tips of microtubules. APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization. The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity).


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