首页 > 重组蛋白 > Human KLK8 Recombinant Protein

KLK8 (基因名), Kallikrein-8 (蛋白名), klk8_human.

产品名称:

Human KLK8/ Kallikrein-8 Recombinant Protein
激肽释放酶8

货号:

R0690h

商标:

EIAab^®

监管等级:

RUO

别名:

Neuropsin, Ovasin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, NP, UNQ283/PRO322, hK8, NRPN, PRSS19, TADG14

序列号:

O60259

来源:

E.coli

种属:

Human

标签:

His

序列:

33-260aa

预估分子量:

25.08 kDa (monomer)

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human KLK8 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 19q13 by HGNC 19q13 by Entrez Gene 19q13 by Ensembl

KLK8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with SPINK9.

功能:

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

亚细胞位置:

Secreted Cytoplasm Shows a cytoplasmic distribution in the keratinocytes.

数据库链接

UniGene:

Hs.104570

SMR:

O60259

KEGG:

hsa:11202

MIM:

605644

Pfam:

PF00089

Uniprot:

O60259

相关产品

序列长度:

260

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

260:

WIKKIIGSKG |

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Proteomic biomarkers for psoriasis and psoriasis arthritis"

Reindl J, Pesek J, Krüger T, et al.

From: Journal of proteomics

[1].

"A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain."

(PMID: 10102990)

[2].

"Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions."

(PMID: 18354391)

[3].

"A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory."

(PMID: 17487847)

[4].

"The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer."

(PMID: 11309326)

[5].

"Sequence analysis and expression of human neuropsin cDNA and gene."

(PMID: 9714609)

[6].

"Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer."

(PMID: 20424135)

[7].

"SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor."

(PMID: 19194479)

[8].

"SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."

(PMID: 17761692)

[9].

"Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005."

(PMID: 16800723)

[10].

"A comprehensive nomenclature for serine proteases with homology to tissue kallikreins."

(PMID: 16800724)

[1].

人激肽释放酶8(KLK8)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人激肽释放酶8(KLK8)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人激肽释放酶8(KLK8)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人激肽释放酶8(KLK8)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人激肽释放酶8(KLK8)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人激肽释放酶8(KLK8)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人激肽释放酶8(KLK8)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人激肽释放酶8(KLK8)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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