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KCNB2 (基因名), Potassium voltage-gated channel subfamily B member 2 (蛋白名), kcnb2_human.
产品名称:

Human KCNB2/ Potassium voltage-gated channel subfamily B member 2 Recombinant Protein
钾电压阀门通道亚家族B成员2

货号:

R2325h

商标:
EIAab®
监管等级:
别名:

Voltage-gated potassium channel subunit Kv2.2

序列号:
Q92953
来源:
E.coli
种属:
Human
标签:
His
序列:
1-190aa
预估分子量:
20.9 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human KCNB2 Protein
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Human KCNB2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 8q21.11 by HGNC 8q21.11 by Entrez Gene 8q21.11 by Ensembl
KCNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.


功能:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.


亚细胞位置:
Cell membrane Multi-pass membrane protein Perikaryon Cell projection Dendrite Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons.


该产品尚未在任何出版物中被引用。

[1].
"Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles."

[2].
"A high-density association screen of 155 ion transport genes for involvement with common migraine."

[3].
"Common genetic variation and performance on standardized cognitive tests."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis."
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