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Kcnj10 (基因名), ATP-sensitive inward rectifier potassium channel 10 (蛋白名), kcj10_mouse.
产品名称:

Mouse Kcnj10/ ATP-sensitive inward rectifier potassium channel 10 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Inward rectifier K(+) channel Kir4.1, Potassium channel, inwardly rectifying subfamily J member 10

序列号:
Q9JM63
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Mouse Kcnj10 Protein
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Mouse Kcnj10 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Heterodimer with Kir5.1/KCNJ16; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. Interacts with MAGI1, alone and possibly as a heterodimer with KCNJ16; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (By similarity). Interacts with PATJ (PubMed:9647694).


功能:
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.


亚细胞位置:
Membrane Multi-pass membrane protein Basolateral cell membrane In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.


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