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JAM3 (基因名), Junctional adhesion molecule C (蛋白名), jam3_human.
产品名称:

Human JAM3/ Junctional adhesion molecule C Recombinant Protein

货号:

R2825h

商标:
EIAab®
监管等级:
别名:

JAM-2, Junctional adhesion molecule 3, JAM-3, UNQ859/PRO1868, JAM-C

序列号:
Q9BX67
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human JAM3 Protein
规格 & 价格: cart
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Human JAM3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q25 by HGNC 11q25 by Entrez Gene 11q25 by Ensembl
JAM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with JAM2. Interacts with ITGAM.


功能:
Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell junction Desmosome Secreted Extracellular space In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945).


该产品尚未在任何出版物中被引用。

[1].
"Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth."

[2].
"JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."

[3].
"Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor."

[4].
"S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration."

[5].
"Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."

[6].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[7].
"Junctional adhesion molecule-C is a soluble mediator of angiogenesis."

[8].
"A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."

[9].
"Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort."

[10].
"Transcriptional induction of junctional adhesion molecule-C gene expression in activated T cells."
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