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JAK1 (基因名), Tyrosine-protein kinase JAK1 (蛋白名), jak1_human.
产品名称:

Human JAK1/ Tyrosine-protein kinase JAK1 Recombinant Protein
酪氨酸蛋白激酶JAK1

货号:

R9729h

商标:
EIAab®
监管等级:
别名:

Janus kinase 1, JAK-1, JAK1A, JAK1B

序列号:
P23458
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human JAK1 Protein
规格 & 价格: cart
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Human JAK1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1p31.3 by HGNC 1p31.3 by Entrez Gene 1p31.3 by Ensembl
JAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with IL31RA (PubMed:15194700). Interacts with IFNAR2 (PubMed:7759950). Interacts with IFNGR1 (PubMed:7615558). Interacts with JAKMIP1 (PubMed:15277531). Interacts with SHB (PubMed:12200137). Interacts with FER.


功能:
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).


亚细胞位置:
Endomembrane system Peripheral membrane protein Wholly intracellular, possibly membrane associated.


该产品尚未在任何出版物中被引用。

[1].
"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase."

[2].
"Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains."

[3].
"Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia."

[4].
"The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors."

[5].
"Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation."
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