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JAGN1 (基因名), Protein jagunal homolog 1 (蛋白名), jagn1_human.
产品名称:

Human JAGN1/ Protein jagunal homolog 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
序列号:
Q8N5M9
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human JAGN1 Protein
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Human JAGN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 3p25.3 by HGNC 3p25.3 by Entrez Gene 3p25.3 by Ensembl
JAGN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with COPA, COPB2 and COPG2.


功能:
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia."

[2].
"Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense."

[3].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[4].
"Novel Mutation in CECR1 Leads to Deficiency of ADA2 with Associated Neutropenia."

[5].
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."

[6].
"JAGN1 Deficient Severe Congenital Neutropenia: Two Cases from the Same Family."

[7].
"Advances in basic and clinical immunology in 2014."

[8].
"Panorama of ancient metazoan macromolecular complexes."

[9].
"A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface."

[10].
"Systematic identification of pathological lamin A interactors."
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