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JAG1 (基因名), Protein jagged-1 (蛋白名), jag1_human.
产品名称:

Human JAG1/ Protein jagged-1 Recombinant Protein
hJ1

货号:

R2164h

商标:
EIAab®
监管等级:
别名:

CD339, Jagged1, JAGL1

序列号:
P78504
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
Human JAG1 Protein
规格 & 价格: cart
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Human JAG1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20p12.2 by HGNC 20p12.2 by Entrez Gene 20p12.2 by Ensembl
JAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions).


功能:
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).


亚细胞位置:
Membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis."

[2].
"Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies."

[3].
"Exon 6 of human JAG1 encodes a conserved structural unit."

[4].
"Putative role of specific JAG1 gene exons in modulating clinical features in patients with leukoencephalopathy."

[5].
"Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans."

[6].
"Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate."

[7].
"Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome."

[8].
"Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage."

[9].
"The significance of human jagged 1 mutations detected in severe cases of extrahepatic biliary atresia."

[10].
"Analysis of cardiovascular phenotype and genotype-phenotype correlation in individuals with a JAG1 mutation and/or Alagille syndrome."
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