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JADE1 (基因名), Protein Jade-1 (蛋白名), jade1_human.
产品名称:

Human JADE1/ Protein Jade-1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Jade family PHD finger protein 1, PHD finger protein 17, KIAA1807, PHF17

序列号:
Q6IE81
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human JADE1 Protein
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Human JADE1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 4q28.2 by HGNC 4q28.2 by Entrez Gene 4q28.2 by Ensembl
JADE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5. Interacts with NPHP4.


功能:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.


亚细胞位置:
Cytoplasm Nucleus Cytoplasm Cytoskeleton Cilium basal body Localizes to the ciliary transition zone.


该产品尚未在任何出版物中被引用。

[1].
"The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."

[2].
"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

[3].
"The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling."

[4].
"Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex."

[5].
"Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL."

[6].
"ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."

[7].
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."

[8].
"Jade-1, a candidate renal tumor suppressor that promotes apoptosis."

[9].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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