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DIO2 (基因名), Type II iodothyronine deiodinase (蛋白名), iod2_human.
产品名称:

Human DIO2/ Type II iodothyronine deiodinase Recombinant Protein
=2\*ROMANII型脱碘

货号:

R0578h

商标:
EIAab®
监管等级:
别名:

5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, ITDI2, TXDI2

序列号:
Q92813
来源:
E.coli
种属:
Human
标签:
His
序列:
1-240aa
预估分子量:
26.4 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human DIO2 Protein
规格 & 价格: cart
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Human DIO2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q31.1 by HGNC 14q31.1 by Entrez Gene 14q31.1 by Ensembl
DIO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with USP20 and USP33. Interacts with MARCH6.


功能:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.


亚细胞位置:
Membrane Single-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients."

[2].
"Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease."

[3].
"The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase."

[4].
"Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population."

[5].
"Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects."

[6].
"The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe."

[7].
"Ala92 type 2 deiodinase allele increases risk for the development of hypertension."

[8].
"The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study."

[9].
"Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome."

[10].
"A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters."
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