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IAPP (基因名), Islet amyloid polypeptide (蛋白名), iapp_human.
产品名称:

Human IAPP/ Islet amyloid polypeptide Recombinant Protein
胰岛淀粉样多肽

货号:

R0812h

商标:
EIAab®
监管等级:
别名:

Amylin, Diabetes-associated peptide, Insulinoma amyloid peptide, DAP

序列号:
P10997
来源:
E.coli
种属:
Human
标签:
His
序列:
1-89aa
预估分子量:
9.79 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human IAPP Protein
  • Human IAPP Protein
  • Human IAPP Protein
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Human IAPP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human IAPP Protein
The PCR product of human IAPP gene was determined by 1% Agarose stained with EB.
Human IAPP Protein
Recombinant human IAPP protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 12p12.1 by HGNC 12p12.1 by Entrez Gene 12p12.1 by Ensembl
IAPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.


功能:
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.


亚细胞位置:
Secreted



[1].
"Missense mutation of amylin gene (S20G) in Japanese NIDDM patients."

[2].
"Cloning and expression of human islet amyloid polypeptide in cultured cells."

[3].
"Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis."

[4].
"S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients."

[5].
"Polymorphism in intron 2 of islet amyloid polypeptide gene is associated with lower low-density lipoprotein cholesterol in nondiabetic subjects and in type 2 diabetic patients."

[6].
"Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site."

[7].
"Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin."

[8].
"Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man."

[9].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[10].
"Identification of type 2 diabetes-associated combination of SNPs using support vector machine."
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