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Gsdme (基因名), Gasdermin-E (蛋白名), gsdme_mouse.
产品名称:

Mouse Gsdme/ Gasdermin-E Recombinant Protein

货号:

R2649m

商标:
EIAab®
监管等级:
别名:

Non-syndromic hearing impairment protein 5 homolog, Dfna5, Dfna5h

序列号:
Q9Z2D3
来源:
E.coli
种属:
Mouse
标签:
His
序列:
271-499aa
预估分子量:
25.19 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Gsdme Protein
规格 & 价格: cart
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Mouse Gsdme Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
Mouse Gsdme Protein
Recombinant mouse Gsdme protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.


功能:
Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (By similarity). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (By similarity).


亚细胞位置:
Gasdermin-E Cytoplasm Cytosol


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