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Ccdc88a (基因名), Girdin (蛋白名), grdn_mouse.
产品名称:

Mouse Ccdc88a/ Girdin Recombinant Protein

货号:

R4164m

商标:
EIAab®
监管等级:
别名:

Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament, Hook-related protein 1, APE, GIV, HkRP1, Grdn, Kiaa1212

序列号:
Q5SNZ0
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Ccdc88a Protein
规格 & 价格: cart
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Mouse Ccdc88a Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [Pi(4)P] and weakly with phosphatidylinositol 3-phosphate [Pi(3)P] (By similarity). Interacts with microtubules. Interacts AKT1/PKB (via C-terminus). Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1.


功能:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (PubMed:15753085). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (PubMed:15753085). Essential for the integrity of the actin cytoskeleton and for cell migration (By similarity). Required for formation of actin stress fibers and lamellipodia (By similarity). May be involved in membrane sorting in the early endosome (By similarity). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein Crocc/Rootletin.


亚细胞位置:
Membrane Cell membrane Cytoplasm Cytosol Cytoplasmic vesicle Cell projection Lamellipodium Cytoplasm Cytoskeleton Cilium basal body Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriole Localizes to the cell membrane through interaction with phosphoinositides.


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