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Fkbp8 (基因名), Peptidyl-prolyl cis-trans isomerase FKBP8 (蛋白名), fkbp8_mouse.
产品名称:

Mouse Fkbp8/ Peptidyl-prolyl cis-trans isomerase FKBP8 Recombinant Protein
肽酰-脯氨酰顺反异构酶FKBP8

货号:

R11198m

商标:
EIAab®
监管等级:
别名:

38 kDa FK506-binding protein, FK506-binding protein 8, FKBPR38, Rotamase, 38 kDa FKBP, FKBP-8, PPIase FKBP8, Fkbp38, Sam11

序列号:
O35465
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Mouse Fkbp8 Protein
规格 & 价格: cart
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Mouse Fkbp8 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin (By similarity). Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.


功能:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development.


亚细胞位置:
Mitochondrion membrane Single-pass membrane protein Cytoplasmic side


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