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DUSP4 (基因名), Dual specificity protein phosphatase 4 (蛋白名), dus4_human.
产品名称:

Human DUSP4/ Dual specificity protein phosphatase 4 Recombinant Protein
双特异性蛋白磷酸酶4

货号:

R12250h

商标:
EIAab®
监管等级:
别名:

Dual specificity protein phosphatase hVH2, Mitogen-activated protein kinase phosphatase 2, MAP kinase phosphatase 2, MKP2, VH2

序列号:
Q13115
来源:
E.coli
种属:
Human
标签:
His
序列:
41-159aa
预估分子量:
13.09 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human DUSP4 Protein
规格 & 价格: cart
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Human DUSP4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 8p12 by HGNC 8p12 by Entrez Gene 8p12 by Ensembl
DUSP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit.


功能:
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase."

[2].
"Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2."

[3].
"Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly."

[4].
"Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)."

[5].
"The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation."

[6].
"Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells."

[7].
"Genome-wide association of lipid-lowering response to statins in combined study populations."

[8].
"Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK."

[9].
"Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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