首页 > 重组蛋白 > Human DDIT3 Recombinant Protein

DDIT3 (基因名), DDIT3 upstream open reading frame protein (蛋白名), dt3uo_human.

产品名称:

Human DDIT3/ DDIT3 upstream open reading frame protein Recombinant Protein
DNA损伤诱导转录因子3

货号:

R9115h

商标:

EIAab^®

监管等级:

RUO

别名:

Alternative DDIT3 protein, AltDDIT3

序列号:

P0DPQ6

来源:

E.coli

种属:

Human

标签:

His

序列:

99-162aa

预估分子量:

7.04 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human DDIT3 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 12q13.3 by HGNC 12q13.3 by Entrez Gene 12q13.3 by Ensembl

DDIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with isoform 1 of DDIT3.

功能:

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

亚细胞位置:

Nucleus Cytoplasm

数据库链接

UniGene:

Hs.505777

SMR:

P35638

STRING:

9606.ENSP00000447803

KEGG:

hsa:1649

MIM:

126337

Pfam:

PF07716

Uniprot:

P0DPQ6

相关产品

Mouse Ddit3 ELISA Kit

Rat Ddit3 ELISA Kit

Bovine DDIT3 ELISA Kit

Mouse Ddit3 CLIA Kit

Rat Ddit3 CLIA Kit

序列长度:

序列:

仅供参考，详细请咨询（services@eiaab.com）

34:

MLKMSGWQRQ | SQNQSWNLRR | ECSRRKCIFI | HHHT

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway."

(PMID: 19722195)

[2].

"DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2."

(PMID: 20017906)

[3].

"Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C/EBP homologous protein."

(PMID: 18541659)

[4].

"CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians."

(PMID: 18680108)

[5].

"Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey."

(PMID: 18977241)

[6].

"Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells."

(PMID: 18772138)

[7].

"Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress."

(PMID: 18534616)

[8].

"Curcumin-induced GADD153 upregulation: modulation by glutathione."

(PMID: 17171638)

[9].

"Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines."

(PMID: 17273769)

[10].

"CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations."

(PMID: 17276738)

[1].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人DNA损伤诱导转录因子3(DDIT3)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人DNA损伤诱导转录因子3(DDIT3)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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