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DEFA5 (基因名), Defensin-5 (蛋白名), def5_human.
产品名称:

Human DEFA5/ Defensin-5 Recombinant Protein
α防御素5

货号:

R1718h

商标:
EIAab®
监管等级:
别名:

Defensin, alpha 5, HD5(20-94), DEF5

序列号:
Q01523
来源:
E.coli
种属:
Human
标签:
His
序列:
20-94aa
预估分子量:
8.25 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
  • Human DEFA5 Protein
  • Human DEFA5 Protein
  • Human DEFA5 Protein
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Human DEFA5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human DEFA5 Protein
The PCR product of human DEFA5 gene was determined by 1% Agarose stained with EB.
Human DEFA5 Protein
Recombinant human DEFA5 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 8p23.1 by HGNC 8p23.1 by Entrez Gene 8p23.1 by Ensembl
DEFA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer.


功能:
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.


亚细胞位置:
Secreted Cytoplasmic vesicle Secretory vesicle Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.


该产品尚未在任何出版物中被引用。

[1].
"Paneth cells of the human small intestine express an antimicrobial peptide gene."

[2].
"Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population."

[3].
"Crystal structures of human alpha-defensins HNP4, HD5, and HD6."

[4].
"Antibacterial activity and specificity of the six human {alpha}-defensins."

[5].
"Enteric defensins are essential regulators of intestinal microbial ecology."

[6].
"Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo."

[7].
"Risk of meningioma and common variation in genes related to innate immunity."

[8].
"Polymorphisms in innate immunity genes and risk of childhood leukemia."

[9].
"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes."

[10].
"A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)."
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