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DAD1 (基因名), Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (蛋白名), dad1_human.
产品名称:

Human DAD1/ Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Recombinant Protein

货号:

R15753h

商标:
EIAab®
监管等级:
别名:

Defender against cell death 1, DAD-1, Oligosaccharyl transferase subunit DAD1

序列号:
P61803
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human DAD1 Protein
规格 & 价格: cart
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Human DAD1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q11.2 by HGNC 14q11.2 by Entrez Gene 14q11.2 by Ensembl
DAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.


功能:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells."

[2].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[3].
"A Large-scale genetic association study of esophageal adenocarcinoma risk."

[4].
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."

[5].
"High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."

[8].
"The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14."

[9].
"The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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