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CYP46A1 (基因名), Cholesterol 24-hydroxylase (蛋白名), cp46a_human.
产品名称:

Human CYP46A1/ Cholesterol 24-hydroxylase Recombinant Protein
胆固醇24-hydroxylase

货号:

R10321h

商标:
EIAab®
监管等级:
别名:

Cholesterol 24-monooxygenase, Cholesterol 24S-hydroxylase, Cytochrome P450 46A1, CH24H, CYP46

序列号:
Q9Y6A2
来源:
E.coli
种属:
Human
标签:
His
序列:
201-500aa
预估分子量:
33 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human CYP46A1 Protein
规格 & 价格: cart
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human CYP46A1 Protein
Recombinant human CYP46A1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 14q32.2 by HGNC 14q32.2 by Entrez Gene 14q32.2 by Ensembl
CYP46A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:25017465, PubMed:18621681). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828).


亚细胞位置:
Endoplasmic reticulum membrane Single-pass membrane protein Microsome membrane Single-pass membrane protein Cell junction Synapse Cell projection Dendrite Detected in the presynaptic and postsynaptic structures.


该产品尚未在任何出版物中被引用。

[1].
"cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain."

[2].
"Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study."

[3].
"CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism."

[4].
"Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes."

[5].
"Association of blood pressure and genetic background with white matter lesions in patients with mild cognitive impairment."

[6].
"Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain."

[7].
"Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease."

[8].
"Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese."

[9].
"[Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease]."

[10].
"Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease."
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