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D7Ertd443e (基因名), (E2-independent) E3 ubiquitin-conjugating enzyme FATS (蛋白名), cj090_mouse.
产品名称:

Mouse D7Ertd443e/ (E2-independent) E3 ubiquitin-conjugating enzyme FATS Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Centrosomal protein C10orf90 homolog, E2/E3 hybrid ubiquitin-protein ligase FATS, Fragile-site associated tumor suppressor homolog, FATS, Fats

序列号:
D2J0Y4
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse D7Ertd443e Protein
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Mouse D7Ertd443e Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723). Interacts with p53/TP53; the interaction inhibits binding of p53/TP53 and MDM2 (PubMed:24240685).


功能:
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage (PubMed:20843368, PubMed:20154723, PubMed:24240685). Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response (PubMed:24240685). Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723). May have a role in the assembly of primary cilia (By similarity).


亚细胞位置:
Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity).


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