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Cdk5r1 (基因名), Cyclin-dependent kinase 5 activator 1 (蛋白名), cd5r1_rat.
产品名称:

Rat Cdk5r1/ Cyclin-dependent kinase 5 activator 1 Recombinant Protein
周期蛋白依赖性激酶激活剂1

货号:

R15082r

商标:
EIAab®
监管等级:
别名:

Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, CDK5 activator 1, Cdk5r

序列号:
P61810
来源:
E.coli
种属:
Rat
标签:
His
序列:
99-307aa
预估分子量:
22.99 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Rat Cdk5r1 Protein
规格 & 价格: cart
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Rat Cdk5r1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Heterodimer composed of CDK5 and CDK5R (p25) and macromolecular complex composed of at least CDK5, CDK5R (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity (By similarity). Interacts with RASGRF2. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4. The complex p35/CDK5 interacts with CLOCK.


功能:
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.


亚细胞位置:
Cyclin-dependent kinase 5 activator 1, p25 Nucleus Cytoplasm Perinuclear region The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions.


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