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Cavin1 (基因名), Caveolae-associated protein 1 (蛋白名), cavn1_mouse.
产品名称:

Mouse Cavin1/ Caveolae-associated protein 1 Recombinant Protein
聚合酶Ⅰ和转录释放因子

货号:

R15153m

商标:
EIAab®
监管等级:
别名:

Cav-p60, Cavin-1, Polymerase I and transcript release factor, Ptrf

序列号:
O54724
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Mouse Cavin1 Protein
规格 & 价格: cart
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Mouse Cavin1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (PubMed:19546242). Homotrimer (PubMed:25588833). Interacts with LIPE in the adipocyte cytoplasm (By similarity). Interacts with RNA polymerase I (PubMed:9582279). Interacts with TTF1 (PubMed:9582279, PubMed:27528195). Binds the 3' end of pre-rRNA (PubMed:9582279). Interacts with transcription factor ZNF148 (PubMed:10727401). Interacts with CAV1, CAVIN2 and CAVIN3 (PubMed:25588833, PubMed:19546242). Interacts with CAVIN4 (PubMed:19546242).


功能:
Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18191225, PubMed:18840361, PubMed:18056712, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:9582279, PubMed:11139612). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967).


亚细胞位置:
Membrane Caveola Cell membrane Microsome Endoplasmic reticulum Cytoplasm Cytosol Mitochondrion Nucleus Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242).


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