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CASP7 (基因名), Caspase-7 (蛋白名), casp7_human.
产品名称:

Human CASP7/ Caspase-7 Recombinant Protein
半胱天冬酶7

货号:

R2266h

商标:
EIAab®
监管等级:
别名:

Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, CASP-7, MCH3

序列号:
P55210
来源:
E.coli
种属:
Human
标签:
His
序列:
1-260aa
预估分子量:
28.60 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human CASP7 Protein
规格 & 价格: cart
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Human CASP7 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human CASP7 Protein
Recombinant human CASP7 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 10q25.3 by HGNC 10q25.3 by Entrez Gene 10q25.3 by Ensembl
CASP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.


功能:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population."

[2].
"Caspase 7 influences susceptibility to rheumatoid arthritis."

[3].
"Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32."

[4].
"ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis."

[5].
"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains."
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