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CASP3 (基因名), Caspase-3 (蛋白名), casp3_human.
产品名称:

Human CASP3/ Caspase-3 Recombinant Protein
胱天蛋白酶3

货号:

R0626h

商标:
EIAab®
监管等级:
别名:

Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, CPP-32, SCA-1, CASP-3, CPP32

序列号:
P42574
来源:
E.coli
种属:
Human
标签:
His
序列:
29-112aa
预估分子量:
9.24 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
  • Human CASP3 Protein
  • Human CASP3 Protein
  • Human CASP3 Protein
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Human CASP3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
The sequence analysis of human CASP3 protein including hydrophilcity, hydrophobicity and antigenicity.
Human CASP3 Protein
Recombinant human CASP3 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 4q35.1 by HGNC 4q35.1 by Entrez Gene 4q35.1 by Ensembl
CASP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.


功能:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone."

[2].
"Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract."

[3].
"CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme."

[4].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[5].
"Genetic susceptibility to distinct bladder cancer subphenotypes."

[6].
"A Large-scale genetic association study of esophageal adenocarcinoma risk."

[7].
"The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia."

[8].
"Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma."

[9].
"A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells."

[10].
"Mutational analysis of caspase genes in prostate carcinomas."
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