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CAPN1 (基因名), Calpain-1 catalytic subunit (蛋白名), can1_human.
产品名称:

Human CAPN1/ Calpain-1 catalytic subunit Recombinant Protein
Calpain-1催化亚基

货号:

R2248h

商标:
EIAab®
监管等级:
别名:

Calcium-activated neutral proteinase 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, CANP 1, muCANP, PIG30, CANPL1

序列号:
P07384
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human CAPN1 Protein
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Human CAPN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q13.1 by HGNC 11q13.1 by Entrez Gene 11q13.1 by Ensembl
CAPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Forms a heterodimer with a small (regulatory) subunit CAPNS1.


功能:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.


亚细胞位置:
Cytoplasm Cell membrane Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719).


该产品尚未在任何出版物中被引用。

[1].
"Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence."

[2].
"Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia."

[3].
"Deimination of human filaggrin-2 promotes its proteolysis by calpain 1."

[4].
"Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells."

[5].
"Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone."

[6].
"Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility."

[7].
"Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core."

[8].
"mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans."

[9].
"Functional dissection of human protease mu-calpain in cell migration using RNAi."

[10].
"Mu-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation."
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