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Bcr (基因名), Breakpoint cluster region protein (蛋白名), bcr_rat.
产品名称:

Rat Bcr/ Breakpoint cluster region protein Recombinant Protein

货号:

R15872r

商标:
EIAab®
监管等级:
序列号:
F1LXF1
来源:
E.coli
种属:
Rat
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Rat Bcr Protein
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Rat Bcr Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homotetramer. Interacts with PDZK1 (By similarity). May interact with CCPG1 (By similarity). Interacts with HCK, FES/FPS, ABL1, PIK3R1 and GRB2 (By similarity). Interacts with SH2D5 (By similarity). Interacts with DLG4 (PubMed:20962234).


功能:
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity).


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Cell projection Dendritic spine Cell projection Axon Cell junction Synapse


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